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In most cases, signsof joint inflammation develop several days after initiation of antibiotic therapy and thesynovial fluid is usually sterile, suggesting an immune complex–mediated phenomenon[19]. Many aspects of pediatric physiology shouldprompt caution against extrapolation of adult data to this group

Many aspects of pediatric physiology shouldprompt caution against extrapolation of adult data to this group.

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These structures de? ne a dimer ofdimers with the four DBD monomers bound to the DNA major groove in the sameDNA face (Fig.